Khoom npe
Leuprolide Acetate
Cas No. 74381-53-6
Sequence: Glp-His-Trp-Ser-Tyr-DLeu-Leu-Arg-Pro-NHEt
Molecular Formula: C59H84N16O12· nC2H4O2(n=1~2)
Molar Mass: 1209.4 · n60.02
Qhov siab tshaj plaws uas tsis tau teev tseg: Tsawg dua lossis sib npaug rau 0.2%
Cia Kub: Chav kub
Ntim Loj: 20G / Lub raj mis, 40G / Lub raj mis lossis ntawm cov neeg siv khoom xav tau.
CAS Nr .:53714-56-0 (net), 74381-53-6 (acetate)
Molecular formula: C59H84N16O12
Molar loj:1209.41
Ib ntus:Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt
Kev siv tshuaj kho mob:Leuprolide yog ib qho tsim tawm ntawm cov tshuaj hormone siv los kho mob qog noj ntshav prostate, mob qog noj ntshav mis, endometriosis, uterine fibroids, thiab thaum ntxov puberty.
Leuprolideyog ib qho hluavtaws 9 residue peptide analog ntawm gonadotropin tso cov tshuaj hormones rau hauv chav kawm ntawm cov tshuaj hu ua cov tshuaj hormones lossis cov tshuaj hormone antagonists. Nws yog siv los kho cov mob qog nqaij hlav prostate, uterine fibroids, thiab endometriosis (nyob rau hauv kev tshawb nrhiav rau kev siv tau hauv kev kho mob me me rau tus kab mob Alzheimer's). Leuprolide kuj tseem siv los kho cov laus laus laus, tswj zes qe menyuam stimulation hauv vitro fertilization (IVF), thiab txo kev sib daj sib deev hauv pedophiles thiab lwm yam mob paraphilia.
Qhov taw qhia
Kev kho mob qog noj ntshav prostate, endometriosis, uterine fibroids, thiab puberty ntxov ntxov.
Pharmacodynamics
Leuprolide yog ib qho luteinizing hormone agonist uas ua rau muaj kev tawm tsam ntawm cov qog ntshav lossis follicular steroidogenesis yog li siv hauv kev kho mob palliative ntawm kev mob qog noj ntshav prostate.
Mechanism ntawm Action
Leuprolide khi rau gonadotropin tso cov tshuaj hormones receptors thiab ua raws li kev ua haujlwm zoo ntawm gonadotropin secretion.
Metabolism
Feem ntau degraded los ntawm peptidase (tsis yog cytochrome P450 enzymes).
Clearance
Kev tso zis hauv zis, 8.34 L / teev [tus txiv neej noj qab haus huv tau txais 1-mg IV bolus]
Kev nqus
Bioavailability los ntawm kev tswj hwm subcutaneous yog piv rau qhov uas los ntawm kev tswj hwm txoj hlab ntshav.
Cim npe nrov: Tuam Tshoj leuprolide acetate manufacturers, hoobkas
